a-actinin mouse mAb(4A12)

簡要描述：SourceMouseApplicationsIHCReactivityHuman

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Source

Mouse
Applications

IHC
Reactivity

Human,Rat,Mouse
Dilution

IHC 1:100-200
Storage

-20°C/1 year
Specificity

a-actinin Monoclonal Antibody(4A12) detects endogenous levels of ACTN1
Source/Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Immunogen

Recombinant Protein of a-actinin of ACTN1
Uniprot No

P12814
Alternative names

ACTN1
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Monoclonal
Isotype

IgG
Background

actinin alpha 1(ACTN1) Homo sapiens Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Other

ACTN1, ACTN1
Concentration

1 mg/ml

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